姓  名: 王延鹏
    职  称: 研究员
    职  务:
    电话/传真: 010-64806907
    电子邮件: yanpengwang@genetics.ac.cn
    实验室主页:
    研究方向: 精准基因组编辑与性状设计

    简历介绍:

    王延鹏,博士,研究员,博士生导师
        2008年获甘肃农业大学学士学位。2011年获西北农林科技大学硕士学位。2016年获中国科学院大学博士学位,论文入选中国科学院优秀博士论文。2016-2019年先后在美国马萨诸塞大学医学院和加州大学戴维斯分校从事博士后研究;2019-2022任遗传与发育生物学研究所青年研究员;2023年起任遗传与发育生物学研究所研究员,课题组组长。获“国家优秀青年基金”资助,入选中国科学院青促会会员,连续五年入选科睿唯安高被引科学家。

    研究领域:

    研究方向:
        通过多学科交叉,开发新型基因组编辑、合成生物学等前沿生物技术,并开展作物性状的精准设计与改良;探索植物新型细胞递送、植物微生物组编辑等新技术和新策略,推进农业的可持续发展。

    社会任职:

    获奖及荣誉:

    承担科研项目情况:

    代表论著:

    Publications(#共同一作;*共同通讯作者):
    2) Zhao, Y#., Huang, Z#., Zhou, X#., Teng, W#., Liu, Z., Wang, W., Tang, S., Liu, Y., Liu, J., Wang, W., Chai, L., Zhang, N., Guo, W., Liu, J., Ni, Z., Sun, Q., Wang, Y*. & Zong, Y*. (2025). Precise deletion, replacement and inversion of large DNA fragments in plants using dual prime editing. Nature Plants, 11, 191–205. https://doi.org/10.1038/s41477-024-01898-3.
    3) Ji, Y., Sun, Y., Zhou, H., Liu, Z., Sun, Z., Xu, G., Wen, H., Zheng, Z., Tu, L., Yang, Z., Zhang, Y., Liu, X., Zhou, S., Dong, X., Wang, Y., Li, C. and Wan, J. (2025), Engineer the eukaryotic OMEGA−Fanzor systems for genome editing in plants. Journal of Integrative Plant Biology, https://doi.org/10.1111/jipb.70049.
    4) Liang Y. and Wang Y*. (2024). Programmable DNA transposon-mediated targeted gene insertion in plants. The Innovation Life, 2(4): 100095. https://doi.org/10.59717/j.xinn-life.2024.100095.
    5) Sun C#, Lei Y#, Li B#, Gao Q, Li Y, Cao W, Yang C, Li H, Wang Z, Li Y, Wang Y, Liu J, Zhao KT*, Gao C*. (2024). Precise integration of large DNA sequences in plant genomes using PrimeRoot editors. Nature Biotechnology, 42, 316–327.
    6) Zhang A#, Shan T#, Sun Y#, Chen Z, Hu J, Hu Z, Ming Z, Zhu Z, Li X, He J, Liu S, Jiang L, Dong X, Wu Y, Wang Y, Liu Y, Li C*, Wan J*. (2023) Directed evolution rice genes with randomly multiplexed sgRNAs assembly of base editors. Plant Biotechnology Journal, 21, 2597-2610.
    7) Zong Y#, Liu Y#, Xue C#, Li B, Li X, Wang Y, Li J, Liu G, Huang X, Cao X*, Gao C*. (2022). An engineered prime editor with enhanced editing efficiency in plants. Nature Biotechnology, doi: 10.1038/s41587-022-01254-w.
    8) Li S#, Lin D#, Zhang Y#, Deng M#, Chen Y, Lv B, Li B, Lei Y, Wang Y, Zhao L, Liang Y, Liu J, Chen K, Liu Z, Xiao J*, Qiu JL*, Gao C*. (2022) Genome-edited powdery mildew resistance in wheat without growth penalties. Nature, 602(7897):455-460. 
    9) Luo J., Rouse M.N., Hua L., Li H., Li B., Li T., Zhang W., Gao C., Wang Y*., Dubcovsky J*. and Chen S*. (2022). Identification and characterization of Sr22b, a new allele of the wheat stem rust resistance gene Sr22 effective against the Ug99 race group. Plant Biotechnology Journal, 20(3):554-563.
    10) Luo G#, Shen L#, Zhao S#, Li R#, Song Y, Song S, Yu K, Yang W, Li X, Sun J., Wang Y, Gao C, Liu D*, Zhang A*. (2021). Genome-wide identification of seed storage protein gene regulators in wheat through coexpression analysis. The Plant journal, 108(6):1704-1720.
    11) Ma S, Wang M*, Wu J, Guo W, Chen Y, Li G, Wang Y, Shi W, Xia G, Fu D, Kang Z, Ni F*. (2021). WheatOmics: a platform combining multiple omics data to accelerate functional genomics studies in wheat. Molecular Plant, 14(12):1965-1968.
    12) Li T#, Hu J#, Sun Y, Li B, Zhang D, Li W, Liu J, Li D, Gao C, Zhang Y*, Wang Y*. (2021). Highly efficient heritable genome editing in wheat using an RNA virus and bypassing tissue culture. Molecular Plant, 14(11):1787-1798.
    13) Lin Q#, Zhu, Z#, Liu G#, Sun C, Lin D, Xue C, Li S, Zhang D, Gao C, Wang Y*,Qiu JL *. (2021). Genome editing in plants with MAD7 nuclease. Journal of Genetics and Genomics, 48(6):444-451. 
    14) Lin Q#, Jin S#, Zong Y#, Yu H#, Zhu Z, Liu G, Kou L, Wang Y, Qiu JL, Li J*, Gao C*.(2021). High-efficiency prime editing with optimized, paired pegRNAs in plants. Nature Biotechnology, 39(8):923-927.
    15) Luo G, Shen L, Song Y, Yu K, Ji J, Zhang C, Yang W, Li X, Sun J, Zhan K, Cui D, Wang Y, Gao C, Liu D*, Zhang A*. (2021). The MYB family transcription factor TuODORANT1from Triticum urartuand homolog TaODORANT1from Triticum aestivuminhibit seed storage protein synthesis in wheat. Plant Biotechnology Journal, 19(9):1863-1877.
    16) Jin S#, Fei H#, Zhu Z#, Luo Y#, Liu J, Gao S, Zhang F, Chen YH, Wang Y*, Gao C*. (2020). Rationally designed APOBEC3B cytosine base editors with improved specificity. Molecular Cell, 79(5):728-740.e6.
    17) Li C, Zong Y, Jin S, Zhu H, Lin D, Li S, Qiu JL, Wang Y*, Gao C*. (2020). SWISS: multiplexed orthogonal genome editing in plants with a Cas9 nickase and engineered CRISPR RNA scaffolds. Genome Biology, 21(1):141.
    18) Lin Q#, Zong Y#, Xue C#, Wang S, Jin S, Zhu Z, Wang Y, Anzalone AV, Raguram A, Doman JL, Liu DR, Gao C*. (2020). Prime genome editing in rice and wheat. Nature Biotechnology, 38(5):582-585.
    19) Si X, Zhang H, Wang Y, Chen K,Gao C*. (2020). Manipulating gene translation in plants by CRISPR-Cas9-mediated genome editing of upstream open reading frames. Nature Protocols, 15(2):338-363.
    20) Chen K#, Wang Y#, Zhang R, Zhang H, Gao C*. (2019) CRISPR/Cas genome editing and precision plant breeding in agriculture. Annual Review of Plant Biology, 70:667-697.
    21) Jin S#, Zong Y#, Gao Q#, Zhu Z, Wang Y, Qin P, Liang C, Wang D, Qiu JL, Zhang F, Gao C*. (2019). Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice. Science, 364(6437):292-295.
    22) Zong Y#, Song Q#, Li C, Jin S, Zhang D, Wang Y, Qiu JL, Gao C*. (2018). Efficient C-to-T base editing in plants using a fusion of nCas9 and human APOBEC3A. Nature Biotechnology, 36(10):950-953.
    23) Li C#, Zong Y#, Wang Y#, Jin S, Zhang D, Song Q, Zhang R, Gao C*. (2018). Expanded base editing in rice and wheat using a Cas9-adenosine deaminase fusion. Genome Biology, 19(1):59.
    24) Zong Y#, Wang Y#, Li C, Zhang R, Chen K, Ran Y, Qiu JL, Wang D, Gao C*. (2017). Precise base editing in rice, wheat and maize with a Cas9- cytidine deaminase fusion.Nature Biotechnology, 35(5):438-440.  
    25) Wang Y, Zong Y, Gao C*. (2017). Wheat genome editing by sequence-specific nucleases. Methods in Molecular Biology, P169-186. DOI 10.1007/978-1-4939-7337-8.
    26) Liang Z , Chen K, Li T, Zhang Y, Wang Y, Zhao Q, Liu J, Zhang H, Liu C, Ran Y, Gao C*. (2017). Efficient DNA-free genome editing of bread wheat using CRISPR/Cas9 ribonucleoprotein complexes. Nature Communications, 8:14261.
    27) Gil-Humanes J, Wang Y, Liang Z, Shan Q, Ozuna C. V, Sanchez-Leon S, Baltes N. J, Starker C, Barro F, Gao C, Voytas D. F*. (2016). High-efficiency gene targeting in hexaploid wheat using DNA replicons and CRISPR/Cas9. The Plant Journal, 89(6):1251-1262.
    28) Zhang Y, Liang Z, Zong Y, Wang Y, Liu J, Chen K, Qiu J, Gao C*. (2016). Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA. Nature Communications, 7:12617.
    29) Ji X, Zhang H, Zhang Y, Wang Y and Gao C*. (2015). Establishing a CRISPR–Cas-like immune system conferring DNA virus resistance in plants. Nature Plants. 1:15144.
    30) Wang Y#, Cheng X#, Shan Q, Zhang Y, Liu J, Gao C*, Qiu JL*. (2014). Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew.Nature Biotechnology, 32(9):947-951.
    31) Shan Q, Wang Y, Li J, Gao C*. (2014). Genome editing in rice and wheat using the CRISPR/Cas system. Nature Protocols. 9(10):2395-2410.
    32) Shan Q#, Wang Y#, Li J#, Zhang Y, Chen K. Liang Z, Zhang K, Liu J, Xi J.J, Qiu JL*, Gao C*. (2013). Targeted genome modification of crop plants using a CRISPR-Cas system. Nature Biotechnology,31(8):686-688.
    33) Shan Q#, Wang Y#, Chen K#, Liang Z, Li J, Zhang Y, Zhang K, Liu J, Voytas D.F, Zheng X, Zhang Y, Gao C*. (2013). Rapid and efficient gene modification in rice and brachypodium using TALENs. Molecular Plant, 6(4):1365-1368.