代表性论文：（*通讯作者）
1. Liang Z, Wu J, Liu Q, Qin D, Wang M, Zhong X*, Guo W*. Targeting lysine α-ketoglutarate reductase to treat pyridoxine-dependent epilepsy. Journal of Neuroscience. 2025; DIO: 10.1523/JNEUROSCI.0370-25.2025.
2. Liang Z, Li Z, Zhang D, Luo X, Liu Q, Wang M, Xu Z, Feng J, He J*, Guo W*. Dual recombinase-mediated intersectional genetics defines the functional heterogeneity of neural stem cell in adult hippocampus. Molecular Psychiatry. 2025; doi: 10.1038/s41380-025-02937-x.
3. Wu J, Qin D, Liang Z, Liu Q, Wang M, Guo Y*, Guo W*. Dysregulation of astrocyte-derived matrix gla protein impairs dendritic spine development in pyridoxine-dependent epilepsy. Molecular Therapy. 2025; 33(4): 1785-1802.
(Commentary: Vitamin K as an add-on therapy in pyridoxine-dependent epilepsy. Houten SM. 2025. Molecular Therapy. 33 (4) 1318-1319).
4. Li Z, Liang Z, Qi H, Luo X, Wang M, Du Z, Guo W*. Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice. Developmental Cell. 2025; 60 (8): 1182-1198.e8.
5. Yan J, Wu J, Xu M, Wang M, Guo W*. Disrupted de novo pyrimidine biosynthesis impairs adult hippocampal neurogenesis and cognition in pyridoxine-dependent epilepsy. Science Advances. 2024; 10(14):eadl2764.
6. Liu Q, Luo X, Liang Z, Qin D, Xu M, Wang M, Guo W*. Coordination between circadian neural circuit and intracellular molecular clock ensures rhythmic activation of adult neural stem cells. Proc Natl Acad Sci U S A. 2024; 121(8):e2318030121.
7. Luo X, Dai M, Wang M, Wang X, Guo W*. Functional heterogeneity of Wnt-responsive and Hedgehog-responsive neural stem cells in the murine adult hippocampus. Developmental Cell. 2023; 58(22):2545-2562.e6.
8. Xu M, Guo Y, Wang M, Luo X, Shen X, Li Z, Wang L, Guo W*. L-arginine homeostasis governs adult neural stem cell activation by modulating energy metabolism in vivo. The EMBO Journal. 2023; 42: e112647.
9. Liu Y, Wang M, Guo Y, Wang L, Guo W*. D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase. Cell Reports. 2023; 42(2):112067.
10. Guo Y, Wu J, Wang M, Wang X, Jian Y, Yang C, Guo W*. The metabolite saccharopine impairs neuronal development by inhibiting the neurotrophic function of glucose-6-phosphate isomerase. Journal of Neuroscience. 2022; 42(13):2631-2646. (Featured Research)
11. Han X, Shen X, Wang M, Wang X, Jian Y, Yang C, Guo W*. Loss of RNA-Binding Protein HuR Leads to Defective Ependymal Cells and Hydrocephalus. Journal of Neuroscience. 2022; 42(2):202-219.
12. Xing R, Zhou H, Jian Y, Li L, Wang M, Liu N, Yin Q, Liang Z, Guo W*, Yang C*. The Rab7 effector WDR91 promotes autophagy-lysosome degradation in neurons by regulating lysosome fusion. Journal of Cell Biology. 2021; 220(8):e202007061.
13. Zhang B, Wang L, Zhan A, Wang M, Tian L*, Guo W*, Pan Y. Long-term exposure to a hypomagenetic field attenuates adult hippocampal neurogenesis and cognition. Nature. Communications. 2021; 12 (1):1174. (Featured Article)
14. Wang M, Tang C, Xing R, Liu X, Han X, Liu Y, Wang L, Yang C*, Guo W*. WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling. Molecular Psychiatry. 2021; 26(2):694-709.
15. Zhao Y, He X, Song Z, Guo Y, Zhang Y, Yu H, He Z, Xiong W, Guo W*, Zhu X*. Human antigen R-regulated mRNA metabolism promotes the cell motility of migrating neurons. Development. 2020. 147 (6):dev183509.
16. Wang Y, Guo Y, Tang C, Han X, Xu M, Sun J, Zhao Y, Zhang Y, Wang M, Cao X, Zhu X, Guo W*. Developmental Cytoplasmic-to-Nuclear Translocation of RNA-Binding Protein HuR Is Required for Adult Neurogenesis. Cell Reports. 2019. 29 (10): 3101-3117.
17. Wang J, Cui Y, Yu Z, Wang W, Cheng X, Ji W, Guo S, Zhou Q, Wu N, Chen Y, Chen Y, Song X, Jiang H, Wang Y, Lan Y, Zhou B, Mao L, Li J, Yang H*, Guo W*, Yang X*. Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis. Cell Stem Cell. 2019. 25(6):754-767.
(Preview: Sensing the Environment: Extracellular Lactate Levels Control Adult Neurogenesis. Scandella V. and Knobloch M. 2019. Cell Stem Cell. 25(6):729-731)
18. Zhou J, Wang X, Wang M, Chang Y, Zhang F, Ban Z, Tang R, Gan Q, Wu S, Guo Y, Zhang Q, Wang F, Zhao L, Jing Y, Qian W, Wang G, Guo W*, Yang C*. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. Journal of Cell Biology. 2019; 218(2):580-597.
(Spotlight: Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin. Leandro J. and Houten SM. 2019; J Cell Biology. 2018(2):391-392.)
19. Tang C, Wang M, Wang P, Wang L, Wu Q, Guo W*. Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN. Neuron. 2019; 101(1):32-44.
(Preview: Interactive Regulation of Neuronal Development by Hippocampal Stem Cell Niche Populations. LeBelle J. and Kornblum H. 2019. Neuron. 101(1):1-2.)
20. Guo Y, Chen X, Xing R, Wang M, Zhu X, Guo W*. Interplay between FMRP and lncRNA TUG1 regulates axonal development through mediating SnoN-Ccd1 pathway. Human Molecular Genetics. 2018; 27(3):475-485.
21. Liu K, Xing R, Jian Y, Gao Z, Ma X, Sun X, Li Y, Xu M, Wang X, Jing Y, Guo W*, Yang C*, WDR91 is a Rab7 effector required for neuronal development. Journal of Cell Biology. 2017; 216(10):3307-3321.
(Spotlight: A new Rab7 effector controls phosphoinositide conversion in endosome maturation. Casanova J. and Winckler B. 2017. J Cell Biology 216(10): 2995-2997)
22. Liu X, Yang Li, Wang X, Xing R, Liu K, Gan Q, Tang C, Gao Z, Jian Y, Luo S, Guo W*, Yang C*, The Beach-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. Journal of Cell Biology. 2017; 216(5):1301-1320.
23. Wang F, Tidei JJ, Polich ED, Gao Y, Zhao H, Perrone-Bizzozero NI*, Guo W*, Zhao X*. Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis. Proc. Natl. Acad. Sci. U S A. 2015; 112(36):E4995-5004.
