Although radiotherapy (RT) has been widely used for tumor treatment, it is still suffered from the following shortcomings, such as serious side effect and the limited efficacy. A novel gold nanocluster-based tumor radiodynamic therapy (RDT) has been developed and successfully applied for efficient tumor treatment. Due to the Type I radiodynamic mechanism, these gold nanoclusters can effectively kill solid tumor even under low dose X-ray irradiation and hypoxia tumor microenvironment. More importantly strong anti-tumor immune response and immune memory effect occurred during the process of RDT, which can effectively prevent potential tumor recurrence or metastasis.

Although radiotherapy (RT) has been widely used for tumor treatment, it is still suffered from the following shortcomings, such as serious side effect and the limited efficacy. A novel gold nanocluster-based tumor radiodynamic therapy (RDT) has been developed and successfully applied for efficient tumor treatment. Due to the Type I radiodynamic mechanism, these gold nanoclusters can effectively kill solid tumor even under low dose X-ray irradiation and hypoxia tumor microenvironment. More importantly strong anti-tumor immune response and immune memory effect occurred during the process of RDT, which can effectively prevent potential tumor recurrence or metastasis.

Although radiotherapy (RT) has been widely used for tumor treatment, it is still suffered from the following shortcomings, such as serious side effect and the limited efficacy. A novel gold nanocluster-based tumor radiodynamic therapy (RDT) has been developed and successfully applied for efficient tumor treatment. Due to the Type I radiodynamic mechanism, these gold nanoclusters can effectively kill solid tumor even under low dose X-ray irradiation and hypoxia tumor microenvironment. More importantly strong anti-tumor immune response and immune memory effect occurred during the process of RDT, which can effectively prevent potential tumor recurrence or metastasis.